11-Day Italy Self-Drive Road Trip With Itinerary from Pescara traveling west to Rome, Florence, Siena, and Perugia
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Escape the ordinary with this exciting 11-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Pescara, 2 nights in Rome, 2 nights in Florence, 2 nights in Siena, and 2 nights in Perugia. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Pescara, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Pescara, Rome, Florence, Pisa, Lucca, Siena, Santa Maria degli Angeli, Perugia, Fano Adriano, and Pietracamela, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
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Day 1
- Pescara - Arrival day
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- Locomotiva FS 740351
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Your road trip adventure in Italy begins as soon as you reach Pescara and pick up your car. You’ll stay in Pescara for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.
Pescara is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Locomotiva Fs 740.351, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
As afternoon approaches, head to your chosen hotel in Pescara. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Pescara, it's often a good idea to reserve a table in advance.
Treat yourself to a wonderful meal at Taverna 58, a top-rated dining spot in Pescara. If you're in the mood for something new, try Ristorante Carlo Ferraioli, another premier location with a delectable menu. You might also want to book a table at Sesamo Nero. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Pescara.
After savoring a delicious meal, step into the vibrant nightlife at Posa Caffè Pescara, where the evening is just getting started. In the same way, Bar Mixer offers a unique charm perfect for experiencing the local bar scene in Pescara. Temple Bar Irish Pub is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.
Raise a toast to the start of your 11-day road trip in Italy!
Day 2
- Pescara
- Rome
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Drive 213 km, 3 hours 15 min
- Colosseum
- Roman Forum
- Altare della Patria
- Pantheon
- Piazza Navona
- More
Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Rome. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Rome. You will spend 2 nights here for some well-deserved relaxation.
Pescara is brimming with adventures. Today’s wonderful stops include an archeological site, a monument, and a public square. Begin your sightseeing adventure at the wondrous Colosseum and allow yourself time to explore. Just a short distance away you'll find your next stop, Roman Forum, a breathtaking archeological site that draws visitors from far and near.
Continue your journey to Altare Della Patria, one of the city’s most locally renowned spots that you shouldn’t miss. Another great site to visit is the world-famous Pantheon. When you're finished at the monument, Piazza Navona awaits your visit. This public square is an enchanting highlight on today's itinerary.
When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.
Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.
Treat yourself to a delightful dinner at La Bottega Roma, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Pasta In Corso? It's another excellent option with a diverse menu. Consider reserving a table at Trattoria Vecchia Roma as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.
Keep the evening going at La Botticella Of Poggi Giovanni, a great choice for enjoying the after-dinner hours with a drink. You could also go to Almalu Trastevere, which offers a similarly pleasant setting and great drinks. Another option is Bar Viminale Di Pepi Maurilio, which provides an inviting environment for unwinding after a busy day out.
Relax and recharge in preparation for another adventurous day in Italy!
Day 3
- Rome
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Drive 9 km, 57 min
- St Peter's Basilica
- piazza del Popolo
- Piazza di Spagna
- Trevi Fountain
- Trastevere
- Via del Corso
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At the end of the day, you'll drive back to Rome, where you'll stay for 1 night more.
Trastevere is a neighborhood that stands out as one of the must-see places in Vatican City. Take a moment to explore its distinct atmosphere, and don’t miss the popular sightseeing spots just a short walk away. For another highlight, head to Via del Corso, a street offering its own unique experiences.
Start your day with a visit to St. Peter's Basilica. This wondrous major basilica is a must-visit in the city. When you’re ready for your next discovery, continue to Piazza Del Popolo, which may be one of the most history-steeped places you will experience today.
One of the best things about exploring Rome on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Piazza Di Spagna, a world-famous public square in the city. If you’re up for more discoveries, don’t forget to reserve some time for Trevi Fountain.
When you’re done exploring for the day, you’ll return to Rome and your accommodation.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Don’t miss out on dining at RomAntica, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Coso Ristorante, another top spot with a mouthwatering menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.
Keep the excitement of the evening going by visiting a bar or two. Sant' Eustachio Caffè is an excellent place to start. You could also check out Yellowsquare Rome, offering a different kind of charm. A last recommendation for the day is Caffè Portofino. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.
Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!
Day 4
- Rome
- Florence
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Drive 282 km, 3 hours 36 min
- The Boboli Gardens
- Ponte Vecchio
- Uffizi Gallery
- Loggia dei Lanzi
- piazza della Signoria
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On day 4 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Florence. When you’re not sightseeing, take time to relax at your selected hotel in Florence, where you’ll be staying for 2 nights.
Prepare for a day full of family-friendly attractions, romantic experiences, and scenic views. When you’re ready, kick off your sightseeing adventure at The Boboli Gardens. This interesting botanical garden is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Ponte Vecchio, one of the city’s best highlights.
Next, check out Uffizi Gallery, one of the most top-rated places to see in Rome. This art gallery is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Loggia Dei Lanzi. Wander around and soak in the history-steeped atmosphere this public square offers. Then, head to Piazza Della Signoria, a top-rated public square that adds another dimension to your day.
At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Treat yourself to a wonderful meal at Ristorante Oliviero 1962, a top-rated dining spot in Florence. If you're in the mood for something new, try Di Poneta Novoli, another premier location with a delectable menu. You might also want to book a table at Caffe San Firenze. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.
Explore the vibrant nightlife at Manifattura after your meal, a hub for lively evenings and memorable moments. Or, head to Se·sto On Arno Rooftop Bar for a great selection of flavorful drinks and a charming setting. Furthermore, Il Vinile is perfect for those looking to extend their night with a touch of local flavor.
Celebrate another amazing day of your road trip adventure in Italy!
Day 5
- Florence
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Drive 6 km, 1 hour 32 min
- piazzale Michelangelo
- Basilica of Santa Croce in Florence
- Cathedral of Santa Maria del Fiore
- Central Market
- Galleria dell'Accademia
- David
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Day 5 of your road trip will take you to the best attractions Florence has to offer. Cherish the 1 night you have left in Florence by discovering the best things there are to see and do in the city.
Start your adventure at Piazzale Michelangelo. This top-rated observation deck is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the heritage-rich wonders of Basilica Of Santa Croce In Florence, a must-see church in the city.
Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Cathedral Of Santa Maria Del Fiore. This spectacular church offers an enriching experience. For a change of pace, head to Central Market, where you can take in eye-catching features. Conclude your self-guided sightseeing tour with a visit to Galleria Dell'accademia and David. These sights offer a fulfilling end to a perfect day.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Enjoy a lovely meal at Ditta Artigianale, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Da Burde is another top choice with a popular menu. You could also check for a table at Casa Toscana. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Florence tonight.
Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Bar 50 Rosso stands out as an excellent choice for a post-dinner cocktail. Alternatively, Bitter Bar offers an ideal atmosphere to enjoy the pleasures of the night. Archea Brewery is also a great option that provides a perfect setting for a relaxing evening.
Celebrate another amazing day of your road trip adventure in Italy!
Day 6
- Florence
- Siena
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Drive 245 km, 3 hours 33 min
- Pisa Cathedral
- Piazza del Duomo, Pisa
- Leaning Tower of Pisa
- Walls of Lucca
- Porta San Pietro
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Embark on another extraordinary experience on day 6 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Pisa and Lucca. At the end of the day, you will enjoy the comforts of a top-rated hotel in Siena, which will be your home away from home for 2 nights.
Brace yourself for today’s incredible lineup of attractions in Florence, featuring fun adventures, scenic views, and picturesque spots. Start at Pisa Cathedral, a frequently visited church in the city. Then, head to Piazza Del Duomo, Pisa and soak in the ambiance of this breathtaking public square.
There are many interesting places to see in Florence, and when you are ready for more, go to Leaning Tower Of Pisa. This is one of the city’s most iconic masterful spots of interest. After exploring the monument, visit the intriguing Mura Di Lucca. Not far away, you'll also find Porta San Pietro. This monument is a historic highlight in Florence.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Siena. Siena offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Treat yourself to a delicious dinner at Enoteca I Terzi, an excellent option for tonight's dining. Looking for something different? Ristorante Tar-Tufo offers a tantalizing alternative with its diverse menu. And don’t miss Antica Trattoria Papei. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Siena.
After enjoying a fulfilling meal, continue your evening at Meet Life Cafè, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Maudit Pub offers a welcoming atmosphere for easing into the nightlife. Similarly, Bar Impero Siena provides an excellent environment for a relaxed and enjoyable evening.
Say good night to Siena and look forward to another great day of your road trip in Italy!
Day 7
- Siena
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Drive 3 km, 59 min
- Porta Camollia, Siena
- Fortezza Medicea
- Fontebranda
- Battistero di San Giovanni Battista
- Siena Cathedral
- piazza del Campo
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Day 7 offers a multitude of experiences. You will stay in Siena for 1 night more, offering you enough time to explore at a relaxed pace.
Get ready to discover some of the most iconic wonders in Siena, including a monument, a historical landmark, a church, a public square and much more! Start your day at Porta Camollia, Siena. This culturally significant monument is an increasingly popular place to see in Siena. Then, wander over to Fortezza Medicea (siena). If historic sites excite you, this monument will be right up your alley. Nearby, you’ll also find Fontebranda. This eye-catching historical landmark is a favorite among visitors.
Siena offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Battistero Di San Giovanni Battista is an underrated spot in the city that will captivate you with its unique charm. When you’re done at the church, don’t forget to check out the inviting Siena Cathedral. Take a moment to appreciate the fascinating details of this captivating church. Wrap up your self-guided tour of Siena's top attractions with a visit to Piazza Del Campo.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As dinnertime approaches, it's time to head out for a bite to eat in Siena. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Dine in style at Osteria Quattro Venti, a top recommendation for dinner tonight. Or, for a change of pace, Fischi per Fiaschi boasts a menu that's sure to impress. Also, be sure to check out Osteria da Divo. Known as a local hotspot, it’s a great choice for tonight in Siena.
Following your dinner, dive into the local bar culture at Charlie Mixology Bar Di Aldinucci Riccardo. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Bar Pinacoteca, the perfect place for those looking to experience the best of the nightlife. Similarly, San Paolo Pub provides excellent drinks and a great atmosphere, ensuring a memorable night out.
Get a good night's sleep and look forward to another great day on the road in Italy!
Day 8
- Siena
- Perugia
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Drive 158 km, 2 hours 50 min
- Basilica of San Francesco d'Assisi
- Piazza del Comune
- Mount Subasio
- San Damiano
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Dive into day 8 of your remarkable road trip in Italy. Today you will explore Santa Maria degli Angeli, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Perugia. You’ll stay here for 2 nights.
Today’s well-planned self-sightseeing route offers several family-friendly attractions, scenic views, and photo-friendly spots. Whether you decide to explore Siena on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Basilica Of San Francesco D'assisi is the first of them. Spend some time admiring this UNESCO world heritage-listed church before continuing your journey. Piazza Del Comune is your next stop. This up-and-coming public square is one of the best-rated sights in Siena.
Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Mount Subasio. This mesmerizing mountain range is a sight to behold. To round off your sightseeing experience, visit San Damiano.
When you’re done exploring for the day, you’ll drive to your hotel in Perugia. Check in and spend some time relaxing before you head out to tour the city.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Perugia. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Make sure to reserve a table at Ristorante Settimo Sigillo, an iconic dining spot in Perugia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Caffè Baglioni, a popular restaurant in Perugia. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Bar Pellas, a hidden gem nestled in Perugia. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Keep the excitement of the evening going by visiting a bar or two. Tommi Bar is an excellent place to start. You could also check out Valentina, offering a different kind of charm. A last recommendation for the day is Caffe Dal Perugino. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 9
- Perugia
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Drive 4 km, 1 hour 2 min
- Chiesa di San Michele Arcangelo
- Acquedotto medievale di Perugia
- Perugia Sotterranea Accesso
- Piazza IV Novembre
- Rocca Paolina
- National Archaeological Museum of Umbria
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Day 9 of your road trip across Italy promises a magnificent time exploring Perugia. You have 1 night left in Perugia. Take the opportunity to experience more of the best attractions and activities in the city.
Today’s agenda in Perugia includes a church, a historical landmark, a cave system, a public square, a museum and much more! Chiesa Di San Michele Arcangelo is must-visit church and a great starting point for the day. Next, continue your journey to Acquedotto Medievale Di Perugia, a beloved historical landmark, located just a leisurely stroll away. Next, head to Perugia Sotterranea Accesso, an eye-catching cave system, also available for your discovery today.
Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Perugia. When you're ready, let your sightseeing route take you to the often recommended Piazza Iv Novembre. If you’re looking for more, Rocca Paolina is also a beloved attraction that is worthwhile a visit. Lastly, don’t miss National Archaeological Museum Of Umbria, a place of standout interest in the city.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a day of adventure, treat yourself to an exquisite dinner at one of Perugia's best restaurants.
Enjoy a delicious meal at La Taverna, a top-rated dining destination in Perugia. If you're in the mood to try something new, consider Ristorante del Sole, another top spot with a mouthwatering menu. You might also want to secure a reservation at Al Mangiar Bene. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Perugia this evening.
After savoring a delicious meal, step into the vibrant nightlife at Caffè Fortebraccio, where the evening is just getting started. In the same way, Caffe Del Banco offers a unique charm perfect for experiencing the local bar scene in Perugia. Dempsey's Perugia is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.
Raise your glass and celebrate another amazing day of your road trip in Italy!
Day 10
- Perugia
- Pescara
- More
Drive 333 km, 6 hours 1 min
- Gran Sasso e Monti della Laga National Park
- Cascata del Rio Arno
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On day 10 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Fano Adriano and Pietracamela. In the evening, you’ll end up in Pescara, where you will stay for 1 night.
Today’s itinerary in Perugia covers several incredible sights, including a national park and a waterfall. Start your adventure at Gran Sasso E Monti Della Laga National Park. This interesting national park is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the mesmerizing wonders of Cascata Del Rio Arno, a must-see waterfall in the city.
These sights offer a fulfilling end to a perfect day.
At the end of the day, you will drive to Pescara, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
After a day of adventure, treat yourself to an exquisite dinner at one of Pescara's best restaurants.
Don’t miss out on dining at Ciacco, a top-rated dining destination in Pescara. If you're in the mood to try something new, consider Bar Sara, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Franco. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Pescara this evening.
Unwind after your meal by stepping into Bar Napoli. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Bar Supermarket offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Post Bar, another top-rated bar in the area.
Take some time to reflect on your day and savor another beautiful night in Italy.
Day 11
- Pescara - Departure day
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- Parrocchia Spirito Santo
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Day 11 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pescara before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
If you're up for some more sightseeing, begin at Parrocchia Spirito Santo. This worthwhile church is a popular place to see in the city.
As your final day in Italy unfolds, enjoy a last-minute shopping spree in Pescara's best shopping area, Centro Commerciale Pescara Porta Nuova. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pescara.
Dine in style at MuuLab. Cucina e Distillati, a top recommendation for dinner tonight. Or, for a change of pace, La Taverna Antica boasts a menu that's sure to impress.
You’ll then say farewell to Pescara. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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