7-Day Italy Self-Drive Road Trip With Itinerary from Brindisi to Matera, Naples, Rome, and Santa Maria degli Angeli

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Escape the ordinary with this exciting 7-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Brindisi, 1 night in Matera, 1 night in Naples, 1 night in Rome, and 1 night in Santa Maria degli Angeli. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Brindisi, Matera, Naples, Pompei, Rome, Santa Maria degli Angeli, and Alberobello, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Lungomare Regina Margherita
Belvedere di Piazza Giovanni PascoliSassi di MateraCasa NohaCattedrale di Maria Santissima della Bruna e Sant'EustachioChurch of Saint Peter 'Barisano'Palombaro lungo
Naples National Archaeological Museumpiazza del PlebiscitoArchaeological Park of Pompeii
ColosseumRoman ForumSt Peter's Basilica
Circus MaximusPiazza NavonaPantheonTrevi FountainSpanish StepsVilla Borghese
Church of Santa Maria sopra Minerva in AssisiChiesa Nuova di San Francesco ConvertitoTrulli di Alberobello Puglia
Saint Pietro of Schiavoni Archeologica Area

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Day 1

Day 1

  • Brindisi - Arrival day
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  • Lungomare Regina Margherita
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Your road trip adventure in Italy begins as soon as you reach Brindisi and pick up your car. You’ll stay in Brindisi for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Brindisi is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Amici Dei Musei Brindisi, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Brindisi. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Bracerie Escosazio, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Penny is another top choice with a popular menu. You could also check for a table at Piadineria. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Brindisi tonight.

Keep the excitement of the evening going by visiting a bar or two. Peddy Bar. Pasticceria. Gelateria. Happyhour. Prodotti Celiaci. Slot Machines. Scommesse is an excellent place to start. You could also check out Eden Cafè, offering a different kind of charm. A last recommendation for the day is Altair Cafè. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Raise a toast to the start of your 7-day road trip in Italy!

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Day 2

Day 2

  • Brindisi
  • Matera
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Drive 156 km, 2 hours 25 min

  • Belvedere di Piazza Giovanni Pascoli
  • Sassi di Matera
  • Casa Noha
  • Cattedrale di Maria Santissima della Bruna e Sant'Eustachio
  • Church of Saint Peter 'Barisano'
  • Palombaro lungo
  • More

On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Matera. In the evening, you’ll end up in Matera, where you will stay for 1 night.

Today’s well-planned self-sightseeing route offers several fun adventures, romantic experiences, and scenic views. Whether you decide to explore Brindisi on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Belvedere Di Piazza Giovanni Pascoli is the first of them. Spend some time admiring this romantic observation deck before continuing your journey. Sassi Di Matera is your next stop. This popular archeological site is one of the best-rated sights in Brindisi.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Casa Noha. This heritage-rich museum is a sight to behold. To round off your sightseeing experience, visit Cattedrale Di Maria Santissima Della Bruna E Sant'eustachio and Church Of Saint Peter 'barisano'. If time allows, end your day with Palombaro Lungo, an UNESCO world heritage-designated cave system that offers a memorable conclusion to your exploration.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Matera. Matera offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Matera. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a lovely dining experience at Ristorante Le Bubbole, a popular restaurant in Matera. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Matera at Baccanti, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated.

Say good night to Matera and look forward to another great day of your road trip in Italy!

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Day 3

Day 3

  • Matera
  • Naples
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Drive 311 km, 4 hours 12 min

  • Naples National Archaeological Museum
  • piazza del Plebiscito
  • Archaeological Park of Pompeii
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Experience an unparalleled adventure on day 3 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Naples and Pompei. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Naples. You will spend 1 night here for some well-deserved relaxation.

Get ready for an exciting day in Matera. Today’s sightseeing agenda includes a museum, a public square, and an archeological site. Begin your adventure at Naples National Archaeological Museum. This is a popular museum you should not miss. Another must-see is Piazza Del Plebiscito, an astonishing public square in Matera.

When you’re ready for the next sight, head to Archaeological Park Of Pompeii.

At the end of the day, you will drive to Naples, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Naples. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at L'Oca Nera Irish Pub, a highly-rated dining destination in Naples. If you're eager to try something different, consider Mimì alla Ferrovia, another top spot with a tantalizing menu. You might also want to secure a reservation at Spuzzulè Winebar. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Naples this evening.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Happening Cocktail Bar, known for its inviting atmosphere. Shanti Art Musik Bar is another great option if you’re looking for a place to get the night started. Similarly, Gran Caffè Gambrinus provides a great setting to enjoy the night away.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 4

Day 4

  • Naples
  • Rome
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Drive 237 km, 3 hours 7 min

  • Colosseum
  • Roman Forum
  • St Peter's Basilica
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Embark on another extraordinary experience on day 4 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Rome and Vatican City. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 1 night.

Get ready for a day filled with family-friendly attractions, scenic views, and photo-friendly spots in the charming city of Naples. Your adventure starts at Colosseum, a timeless local hot spot. Another notable attraction to explore is Roman Forum. This wondrous archeological site is known for its historic appeal.

After soaking in the highlights of these sights, take some time to wander Naples's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to St. Peter's Basilica.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Don’t miss out on dining at La Bottega Roma, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Pasta In Corso, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Vecchia Roma. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Cap off your dinner by heading to La Botticella Of Poggi Giovanni, ideal for a leisurely evening with a drink in hand. Almalu Trastevere is another bar that offers an enjoyable setting. Similarly, Bar Viminale Di Pepi Maurilio is also a popular place to go on a night out, perfect for relaxing and socializing.

Raise your glass to another unforgettable day in Italy!

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Day 5

Day 5

  • Rome
  • Assisi
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Drive 189 km, 3 hours 19 min

  • Circus Maximus
  • Piazza Navona
  • Pantheon
  • Trevi Fountain
  • Spanish Steps
  • Villa Borghese
  • More

On day 5 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Santa Maria degli Angeli, where you’ll be staying for 1 night.

Savor the day by visiting some of the best places to see in Rome, including an archeological site, a public square, a monument, a park and much more! Start your adventure at Circus Maximus. This captivating archeological site is a must-visit for travelers looking for a unique holiday experience. Make your way to Piazza Navona located in Rome for another exciting encounter.

Next, immerse yourself in the setting of Pantheon. Its culturally significant features will captivate you. After the monument, continue your tour of the city with a visit to Trevi Fountain. Visitors usually appreciate the culturally significant features of this monument. Next up is Spanish Steps, a highly recommended public square. For a change of pace, head to Villa Borghese. As one of the most famous attractions in Rome, this park is the perfect place to end your self-guided sightseeing tour.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Santa Maria degli Angeli. Santa Maria degli Angeli offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Santa Maria degli Angeli's most popular restaurants, and connect with friendly locals for an authentic adventure.

Following your dinner, dive into the local bar culture at Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings. Enjoy this evening's relaxed ambiance with delightful drinks.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 6

Day 6

  • Assisi
  • Brindisi
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Drive 676 km, 7 hours 18 min

  • Church of Santa Maria sopra Minerva in Assisi
  • Chiesa Nuova di San Francesco Convertito
  • Trulli di Alberobello Puglia
  • More

Dive into day 6 of your remarkable road trip in Italy. Today you will explore Santa Maria degli Angeli and Alberobello, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Brindisi. You’ll stay here for 1 night.

Today, you'll explore some of the most beautiful places in Santa Maria degli Angeli, including a church and a historical landmark. Start your day with a visit to Church Of Santa Maria Sopra Minerva In Assisi. This curiosity-inducing church is a must-visit in the town. When you’re ready for your next discovery, continue to Chiesa Nuova Di San Francesco Convertito, which may be one of the most culturally significant places you will experience today.

One of the best things about exploring Santa Maria degli Angeli on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Trulli Di Alberobello Puglia, a well-known historical landmark in the town.

At the end of the day, you will drive to Brindisi, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Brindisi. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Dine in style at Betty - Gelateria Cafe Ristorante Pizzeria a Brindisi, a top recommendation for dinner tonight. Or, for a change of pace, Bento boasts a menu that's sure to impress. Also, be sure to check out Cozza Nera. Known as a local hotspot, it’s a great choice for tonight in Brindisi.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 7

Day 7

  • Brindisi - Departure day
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  • Saint Pietro of Schiavoni Archeologica Area
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Day 7 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Brindisi before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Saint Pietro Of Schiavoni Archeologica Area. This underrated archeological site is a popular place to see in the city.

Make the most of your final day in Italy by visiting Brindisi’s iconic markets and shopping establishments. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Brindisi.

If you're eager to try something different, consider Pizzeria La Nassa, another top spot with a tantalizing menu.

You’ll then say farewell to Brindisi. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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