12-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling south to Savona, Florence, Rome, and Siena
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Experience the freedom of the open road in Italy as you embark on an unforgettable 12-day road trip! This experience caters to every traveler, featuring destinations like Genoa, Savona, Santa Margherita Ligure, Rapallo, Florence, Tivoli, Rome, Pescia Fiorentina, Ansedonia, Grosseto, Siena, and San Piero a Grado.
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 1 night in Savona, 3 nights in Florence, 4 nights in Rome, and 1 night in Siena. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Genoa, Savona, Santa Margherita Ligure, Rapallo, Florence, Tivoli, Rome, Pescia Fiorentina, Ansedonia, Grosseto, Siena, and San Piero a Grado, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
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Day 1
- Genoa - Arrival day
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- Piazza Corvetto
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Say hello to Genoa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Genoa for 1 night before you continue your adventure!
Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza Corvetto, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.
Enjoy a lovely dining experience at 7 Sensi cucina decontaminata, a popular restaurant in Genoa. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Genoa at Alla Lunga Ristorante, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Grand Hotel Savoia. It’s yet another ideal choice to enhance your time in Genoa tonight.
Explore the vibrant nightlife at Scurreria Beer & Bagel after your meal, a hub for lively evenings and memorable moments. Or, head to La Lepre for a great selection of flavorful drinks and a charming setting. Furthermore, Bar Pisacane Iii is perfect for those looking to extend their night with a touch of local flavor.
Raise a toast to the start of your 12-day road trip in Italy!
Day 2
- Genoa
- Savona
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Drive 46 km, 1 hour 1 min
- piazza De Ferrari
- Doge's Palace
- Genoa Cathedral
- Aquarium of Genoa
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On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Genoa. When you’re not sightseeing, take time to relax at your selected hotel in Savona, where you’ll be staying for 1 night.
Piazza De Ferrari is must-visit public square and a great starting point for the day. Next, continue your journey to Doge's Palace, a worthwhile museum, located just a leisurely stroll away. Next, head to Genoa Cathedral, a culturally significant church, also available for your discovery today.
At the end of the day, you will drive to Savona, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Savona. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Enjoy a lovely dining experience at Il Mondo Del Caffè, a popular restaurant in Savona. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Savona at Club Nautico di Savona, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated.
Explore the vibrant nightlife at Fuoritutti Food & Beer after your meal, a hub for lively evenings and memorable moments.
Head back to your accommodation in Savona and get some rest in preparation for another magical day of your road trip in Italy!
Day 3
- Savona
- Genoa
- Florence
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Drive 307 km, 4 hours 9 min
- Lighthouse of Genoa
- Spiaggia Libera
- Il Giardino di Villa Durazzo
- Rapallo Castle
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On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Genoa, Santa Margherita Ligure, and Rapallo. In the evening, you’ll end up in Florence, where you will stay for 3 nights.
Today’s route brings fun adventures, scenic views, and picturesque spots. The first attraction of today is Lighthouse Of Genoa. This often recommended lighthouse is a historic place to see in Savona. Continue your discovery at Spiaggia Libera, an eye-catching beach with stories to tell.
As you stroll around Savona, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Villa Durazzo. This intriguing palace offers a romantic encounter with Savona. Next, make your way to Rapallo Castle to add another highlight to your day. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Savona.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.
Start your culinary exploration in Florence by securing a reservation at Enoteca Pinchiorri. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of italian contemporary cuisine. For another dining delight, visit Santa Elisabetta, celebrated for its delectable creative and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Gucci Osteria da Massimo Bottura, a top local spot known for its tantalizing italian contemporary and international menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.
To truly maximize your evening out, consider visiting Manifattura after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Se·sto On Arno Rooftop Bar, another bar with an inviting ambiance. Similarly, Il Vinile also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.
Take some time to reflect on your day and savor another beautiful night in Italy.
Day 4
- Florence
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Drive 7 km, 52 min
- Ponte Vecchio
- Uffizi Gallery
- piazza della Signoria
- Basilica of Santa Croce in Florence
- piazzale Michelangelo
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Day 4 offers a multitude of experiences. You will stay in Florence for 2 nights more, offering you enough time to explore at a relaxed pace.
Brace yourself for today’s incredible lineup of attractions in Florence, featuring fun adventures, romantic experiences, and breathtaking views. Start at Ponte Vecchio, a timeless historical landmark in the city. Then, head to Uffizi Gallery and soak in the ambiance of this picture-perfect art gallery.
There are many interesting places to see in Florence, and when you are ready for more, go to Piazza Della Signoria. This is one of the city’s most extraordinary visually striking spots of interest. After exploring the public square, visit the well-known Basilica Of Santa Croce In Florence. Not far away, you'll also find Piazzale Michelangelo. This observation deck is a romantic highlight in Florence.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Treat yourself to a wonderful meal at Ditta Artigianale, a top-rated dining spot in Florence. If you're in the mood for something new, try Trattoria Da Burde, another premier location with a delectable menu. You might also want to book a table at Casa Toscana. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.
If you’re not ready to end the night just yet, Bar 50 Rosso offers a perfect venue to relax and savor a drink. Similarly, Bitter Bar is well-suited for those looking to unwind in a social setting. Archea Brewery is another excellent spot to enjoy a nightcap after a delightful meal.
Savor another day of unforgettable experiences in Italy!
Day 5
- Florence
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Drive 3 km, 49 min
- Galleria dell'Accademia
- Cathedral of Santa Maria del Fiore
- Central Market
- Basilica of Santa Maria Novella
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Day 5 of your road trip will take you to the best attractions Florence has to offer. Cherish the 1 night you have left in Florence by discovering the best things there are to see and do in the city.
Florence is brimming with adventures. Today’s wonderful stops include an art gallery, a church, and a food market. Begin your sightseeing adventure at the locally renowned Galleria Dell'accademia and allow yourself time to explore. Just a short distance away you'll find your next stop, Cathedral Of Santa Maria Del Fiore, an enchanting church that draws visitors from far and near.
Continue your journey to Central Market, one of the city’s most well-known spots that you shouldn’t miss. Another great site to visit is the well-known Basilica Di Santa Maria Novella, Firenze (fi).
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.
Make sure to reserve a table at Ristorante Buca Mario, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Agricola Toscana, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Eataly Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Following your dinner, dive into the local bar culture at Gosh*. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Antico Caffè Del Moro - Art Bar Firenze, the perfect place for those looking to experience the best of the nightlife. Similarly, Quelo Bar provides excellent drinks and a great atmosphere, ensuring a memorable night out.
Celebrate another amazing day of your road trip adventure in Italy!
Day 6
- Florence
- Rome
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Drive 325 km, 4 hours 19 min
- Villa d'Este
- Saint Peter's Square
- St Peter's Basilica
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Embark on another extraordinary experience on day 6 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Tivoli and Vatican City. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 4 nights.
Immerse yourself in Florence’s rich culture with today's sightseeing itinerary. Start your journey at Villa D'este. This visually striking palace is sure to ignite your curiosity.
In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to St. Peter's Basilica, a timeless major basilica.
When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.
As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Dive into a culinary adventure like no other in Rome by booking a table at La Pergola. This popular restaurant holds 3 Michelin star and offers an exceptional menu of mediterranean and contemporary cuisine. For another culinary dining option, venture to Il Pagliaccio, celebrated for its delectable creative and innovative menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, ensuring an essential addition to your holiday itinerary. Seeking an alternative? Discover Enoteca La Torre, a top local restaurant known for its tantalizing mediterranean and creative menu. With a 2-star Michelin recognition, it promises an exceptional dining experience not to be missed.
Continue your lively evening at La Botticella Of Poggi Giovanni, a perfect place for winding down or revving up the night, depending on which mood you’re in. Almalu Trastevere is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Bar Viminale Di Pepi Maurilio ensures a night out tailored to your taste.
As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.
Day 7
- Rome
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Drive 5 km, 1 hour 15 min
- Piazza Navona
- Pantheon
- Roman Forum
- Colosseum
- Circus Maximus
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Day 7 of your road trip across Italy promises a magnificent time exploring Rome. You have 3 nights left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.
Set out on a day brimming with family-friendly attractions, romantic experiences, and scenic views. Start at the wondrous Piazza Navona, a history-steeped public square in Rome. Next, go to Pantheon.
After visiting Piazza Navona and Pantheon, have a stroll along Rome's streets and take in the local charm. Continue your sightseeing by heading to Roman Forum. This picture-perfect archeological site offers a unique experience. Colosseum is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Circus Maximus, one of the most picture-perfect places to visit in Rome.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Make sure to reserve a table at RomAntica, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Coso Ristorante, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of DEROMA - Farine Romane, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Sant' Eustachio Caffè, a well-loved spot among locals and tourists. Or, head to Yellowsquare Rome. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Caffè Portofino, another top-rated place in the area.
Raise your glass and celebrate another amazing day of your road trip in Italy!
Day 8
- Rome
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Drive 13 km, 1 hour 16 min
- Basilica di Santa Maria Maggiore
- Altare della Patria
- Trevi Fountain
- Piazza di Spagna
- Spanish Steps
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On day 8 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 2 nights and discover all the best things to see and do in the area.
Today’s route brings fun adventures, picturesque spots, and historic treasures. The first attraction of today is Basilica Di Santa Maria Maggiore. This well-known church is a photogenic place to see in Rome. Continue your discovery at Altare Della Patria, a masterful monument with stories to tell.
As you stroll around Rome, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Trevi Fountain. This wondrous monument offers a history-steeped encounter with Rome. Next, make your way to Piazza Di Spagna to add another highlight to your day. After that, visit Spanish Steps, an extraordinary public square that’s sure to impress. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Rome.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Dine in style at Hotel de Russie, a top recommendation for dinner tonight. Or, for a change of pace, La Taverna Italiana boasts a menu that's sure to impress. Also, be sure to check out The Parrot Bar. Known as a local hotspot, it’s a great choice for tonight in Rome.
Round off your dining experience by visiting The Apartment Bar Roma, a prime location for a drink. Alternatively, explore the distinctive characteristics of Hotel Hassler Roma, a bar catering to every mood and preference.
Say good night to Rome and look forward to another great day of your road trip in Italy!
Day 9
- Rome
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Drive 10 km, 1 hour 5 min
- Villa Borghese
- piazza del Popolo
- Castel Sant'Angelo
- Campo de' Fiori
- largo di Torre Argentina
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Day 9 offers a multitude of experiences. You will stay in Rome for 1 night more, offering you enough time to explore at a relaxed pace.
Savor the day by visiting some of the best places to see in Rome, including a park, a public square, a castle, an archeological site and much more! Start your adventure at Villa Borghese. This widely recognized park is a must-visit for travelers looking for a unique holiday experience. Make your way to Piazza Del Popolo located in Rome for another exciting encounter.
Next, immerse yourself in the setting of Castel Sant'angelo. Its history-steeped features will captivate you. After the castle, continue your tour of the city with a visit to Campo De' Fiori. Visitors usually appreciate the romantic features of this public square. Next up is Largo Di Torre Argentina, a highly recommended archeological site.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.
Enjoy a lovely dining experience at Sofitel Roma Villa Borghese, a popular restaurant in Rome. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Rome at Centro, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Ristorante Tema. It’s yet another ideal choice to enhance your time in Rome tonight.
Relax and reminisce about your day in Italy and look forward to more memorable moments to come!
Day 10
- Rome
- Siena
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Drive 261 km, 3 hours 37 min
- The Tarot Garden
- Spacco della Regina
- River Park Ombrone Silvano Signori
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Experience an unparalleled adventure on day 10 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Pescia Fiorentina, Ansedonia, and Grosseto. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Siena. You will spend 1 night here for some well-deserved relaxation.
A blend of family-friendly attractions, romantic experiences, and scenic views await you in Rome on today’s itinerary. First up is the increasingly popular sculpture garden, The Tarot Garden. Afterward, continue to Spacco Della Regina, a cave every traveler should visit.
As you explore Rome’s charming streets, take in the lively atmosphere and get to know the character of the village. Next, make your way to River Park Ombrone Silvano Signori. This intriguing park is an essential stop.
At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
As you explore more of Siena, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Make sure to reserve a table at Enoteca I Terzi, an iconic dining spot in Siena. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Ristorante Tar-Tufo, a popular restaurant in Siena. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Antica Trattoria Papei, a hidden gem nestled in Siena. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Let the evening flow smoothly from dinner to drinks at Meet Life Cafè, a top-rated bar in the area. For other recommendations, Maudit Pub provides a perfect setting for rounding out your night with style and great drinks. Likewise, Bar Impero Siena offers a memorable night with diverse drink options and excellent service.
Celebrate another amazing day of your road trip adventure in Italy!
Day 11
- Siena
- Genoa
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Drive 297 km, 3 hours 55 min
- piazza del Campo
- Siena Cathedral
- Church of Saint Peter a Grado
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Dive into day 11 of your remarkable road trip in Italy. Today you will explore Siena and San Piero a Grado, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Genoa. You’ll stay here for 1 night.
Savor the day by visiting some of the best places to see in Siena, including a public square and a church. Start your adventure at Piazza Del Campo. This spectacular public square is a must-visit for travelers looking for a unique holiday experience. Make your way to Siena Cathedral located in Siena for another exciting encounter.
Next, immerse yourself in the setting of San Piero A Grado. Its stunning features will captivate you.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
After a day of adventure, treat yourself to an exquisite dinner at one of Genoa's best restaurants.
Prepare for an extraordinary culinary adventure in Genoa by booking a table at San Giorgio, a 1-star Michelin restaurant that boasts an exceptional modern and ligurian menu. For a different flavor experience, head to The Cook, renowned for its delectable modern dishes. This 1-star Michelin restaurant consistently wows guests, making it a memorable stop during your holiday. Looking for another option? Visit Il Marin, a local gem known for its delightful seafood and contemporary cuisine in Genoa. Nestled in the city's heart, this 1-star Michelin restaurant is a perfect choice for discerning restaurant-goers seeking a new experience.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 12
- Genoa - Departure day
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- Via Garibaldi
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Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
If you're up for some more sightseeing, we recommend visiting Via Garibaldi, an UNESCO world heritage-listed street before you head out.
As your final day in Italy unfolds, enjoy a last-minute shopping spree in Genoa's best shopping area, Via XX Settembre. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.
Treat yourself to a delightful dinner at Osteria Sant'Ilario, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La Cialtroneria? It's another excellent option with a diverse menu.
You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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